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In addition, polymeric poly(styrene-comaleic anhydride) (PSMA)-NPs and conjugated polymer poly[2-methoxy-5-(2-ethylhexoxy)-1,4-styreneyl](PPV) -PSMA-NPs nanoparticles prepared by nanoprecipitation have also been shown to reverse the immunosuppressive TME by reprogramming TAMs, and which can not only specifically target TAMs but also directly inhibit tumor growth by repolarizing TAMs to kill tumor M1 phenotype (60)

Beyond its role as a protector, glutathione is a heavy lifter in the detoxification process